Discovering Rheumatoid Arthritis During Pregnancy
Abstract
Rheumatoid arthritis is an autoimmune mechanism disease that preferentially affects women. Remission from rheumatoid arthritis has often been associated with pregnancy.
A 29-year-old woman presented with symmetrical inflammatory polyarthralgias of the large and small joints with morning stiffness estimated at 5 hours, and the Visual Analogue Scale at 80/100 associated with the joint swelling onset 12th week of amenorrhea. She has no medical history, third pregnancy, and no fetal loss has been reported. The physical examination of the day objectified five painful joints and two swollen joints. Disease activity was moderate. There was a biological inflammatory syndrome with a C-Reactive Protein (CRP) at 37.9 mg. Rheumatoid factor was positive at 214 IU (Standard <14 IU), anti-citrullinated peptides antibodies at 99.6 IU (Standard <17 IU).
The pregnancy revealed rheumatoid arthritis positive to rheumatoid factor and citrullinated cyclic anti-peptide antibodies.
References
2. Aletaha D, Neogi T, Silman AJ, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League against rheumatism collaborative initiative. Ann Rheum Dis 2010; 69: 1580–8.
3. Dubucquoi S, Caron C, Hennache B. Interprétation des examens biologiques au cours de la grossesse. Rev rhum 2005 ; 72 : 698–706.
4. Bokarewa MI, Wramsby M, Bremme K. Reactivity against phospholipids during pregnancy. Hum Reprod 1998; 13: 2633–5.
5. Petri M. Pregnancy and rheumatic diseases. Rheum Dis Clin North Am 1997; 1: 1-208.
6. Beagley KW, Gockel CM. Regulation of innate and adaptative immunity by the female sex hormones estradiol and progesterone. FEMS Immunol Med Microbiol 2003; 18 :13–22.
7. Poole JA, Claman HN. Immunology of pregnancy: implications for the mother. Clin Rev Allergy Immunol 2004; 26: 161–70.
8. Somerset DA, Zheng Y, Kilby MD, Sansom DM, Drayson MT. Normal human pregnancy is associated with an elevation in the immune suppressive CD25+CD4+ regulatory T-cell subset. Immunology 2004; 112 : 38–43.
9. Moffet A, Loke YW. The immunological paradox of pregnancy: a reappraisal. Placenta 2004; 25: 1–8.
Copyright (c) 2021 Journal of Rare Diseases and Orphan Drugs
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.