Targeting Tumor Suppressor Genes by miR-141 Family as a Potential Regulatory Function in Cervical Cancer
Potential role of microRNA-141 in cervical cancer
Abstract
Abstract. Introduction: Historically, microRNA is a nanosecond order of single beachfront RNA, hairpin in structure, and roughly 22 nucleotides in the mature phase. Before three decades ago, we did not know about this crucial cellular element. The primary function of miRNAs is targeting and regulating certain gene expressions; therefore, the miRNAs are involved in various human diseases and medical disorders, including infectious diseases and cancer. Identifying potential targeted genes by specific miRNA is essential to recognize, investigate, and treat any related illness. Notably, the miR-200 family, including a cluster of miR-200a, miR-200b, miR-429, and miR-141, has been reported as an essential miRNA aberrantly expressed in several human cancers and involved in cancer initiation and invasion, angiogenesis and metastasis, and cancer diagnosis and therapy.
Methods: PicTar (https://pictar.mdc-berlin.de/cgi-bin/PicTar_vertebrate.cgi), an algorithm, was used to identify microRNA targets.
Results: In this bioinformatics-based study, we identified the potential targeted genes by the miR-200 family using PicTar software to predict the molecular function of the miR-200 family in cancer development. The most identified targets with low required energy and high PicTar score include a variety of tumor and metastasis suppressor genes, such as the metastasis suppressor gene MTSS1 deleted liver cancer -1 (DLC-1) that are regulated by miR-200a and miR141, respectively. The deficient energy required for targeting these genes and completing the interfering reaction makes it a straightforward and spontaneous cellular event.
Conclusion: The miR-200 family by its members, especially mi, strongly impacted cancer development and metastasis types, including cancer cervix.
References
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