A 71-Year-Old Man Presenting with Anemia and a Solitary Skin Lesion Associated with Primary Cutaneous Marginal Zone Lymphoma

  • Mariya Khudyakova The Department of Internal Medicine B, Lady Davis Carmel Medical Center, Haifa, Israel
Keywords: Autoimmune hemolytic anemia, therapy-resistant anemic syndrome, primary cutaneous marginal zone lymphoma, elderly, multimorbidity


A 71-year-old man with a solitary red lesion on his left arm, which initially thought to be a hematoma, was admitted for inpatient evaluation of anemia, which after a positive direct Coombs test was qualified as autoimmune hemolytic anemia. The patient also presented with hoarseness and biopsies from the swelled nasopharynx and an enlarged right tonsil were obtained. Due to uncertain diagnosis and the patient’s previous history of malignancy, (low grade lymphoproliferative lymphoma) skin and bone marrow biopsies were performed. Unfortunately, the patient’s status rapidly deteriorated as a result of septic shock. The obtained skin, nasopharynx, and tonsil biopsies became available after the patient died and showed marginal zone lymphoma with no evidence of lymphoproliferative neoplasm in the bone marrow.   

This case demonstrates the diagnostic complexity of nodal marginal zone lymphoma complicated by severe life-threatening autoimmune hemolytic anemia in an elderly patient with multimorbidity, which presents management challenges for health care providers.


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How to Cite
Khudyakova, M. (2021). A 71-Year-Old Man Presenting with Anemia and a Solitary Skin Lesion Associated with Primary Cutaneous Marginal Zone Lymphoma. Journal of Internal Medicine: Science & Art, 2(1), 25 - 28. https://doi.org/10.36013/jimsa.v2i1.53